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A small hole of just six millimeters is enough for mice to enter homes, especially during colder months. Experts emphasize the importance of sealing any openings larger than 0.6 centimeters to prevent infestations. Mice reproduce quickly, making it crucial to check various entry points, including windows, walls, and ventilation systems. Signs of potential entry include light visible under doors or around windows. Proper prevention involves maintaining cleanliness, securing food, and regularly inspecting areas like garages and attics. Keeping trash sealed and trimming bushes can also deter mice from approaching homes.