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Regularly changing bed sheets is not enough to keep a mattress clean. Dust, dead skin cells, and pet hair accumulate over time, creating a breeding ground for allergens. It is recommended to vacuum the mattress at least twice a year, but more frequent cleaning is necessary if you have pets or allergies. Proper vacuuming techniques should be used to avoid damaging the mattress. Additionally, maintaining overall bedroom hygiene, including washing bedding and airing out the room, is essential for a healthy sleeping environment.