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Researchers at Mayo Clinic have identified five distinct subtypes of fatty liver disease, which could lead to better health risk predictions and personalized treatments. The study, published in "Nature Communications," analyzed genetic data and medical records of 4,600 patients. It found that some subtypes are linked to metabolic issues like obesity and diabetes, while others are influenced by genetics. Certain genetic forms increase the risk of severe liver damage, even without common risk factors. The findings may change how MASLD is diagnosed and treated, paving the way for personalized medicine. Further research is needed to validate these results and explore treatment responses.