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Radiotherapy initiation involves careful planning and evaluation tailored to each patient and tumor type. Before treatment begins, oncological assessment, simulation, and precise planning are essential. The multidisciplinary oncology team determines the treatment order, which may vary among patients with similar diagnoses. Radiotherapy can be curative, complement surgery, or alleviate symptoms. The process starts with patient positioning and CT imaging for treatment planning, followed by dose distribution calculations. Modern radiotherapy includes verification of the plan and patient positioning checks during sessions before the first treatment fraction is administered.