Anestezia cu ketamină produce schimbări surprinzătoare în creier

Researchers found that ketamine anesthesia enhances brain plasticity and neural remodeling in female mice, revealing complex effects of the drug. The study showed increased microglial interaction with neurons, promoting synapse formation, which is linked to neuroplasticity. Corticosterone, a stress hormone, plays a crucial role in this process, activating specific genes in microglia. Notably, these effects were not observed in male mice, suggesting sex-based differences in brain remodeling mechanisms. The findings have implications for understanding ketamine's therapeutic potential in treating depression, highlighting the need for further research on gender differences in drug responses.